منابع مشابه
Are companion diagnostics useful?
We define a companion diagnostics (CDx) test as any diagnostic tool that guides the selection of patient treatment. In the US, these tests include diagnostics cleared by the Food and Drug Administration (FDA), as well as laboratory-developed tests (LDTs) run in CLIA-accredited laboratories. The answer to the title’s question is obviously in the affirmative. We discuss the growing need to improv...
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At the European Multidisciplinary Cancer Congress (EMCC), held in Stockholm in September 2011, a recurring theme in many of the workshops was personalised medicine, including the latest developments in prognostic and predictive biomarkers. Such markers, it is hoped, will enable clinicians to use available resources to best effects-by offering treatments to only those patients most likely to ben...
متن کاملThe Retrospective Approach To Companion Diagnostics
Companion diagnostic tests, developed for use in conjunction with therapeutic drugs and biologics, drive personalized medicine. These tests, which are regulated by the U.S. Food and Drug Administration as medical devices when they are marketed as kits,[1] are indispensable to personalized medicine because they provide “information that is essential for the safe and effective use of a correspond...
متن کاملChallenges in the codevelopment of companion diagnostics
The goal of personalized medicine, to effectively customize diagnosis, treatment and prevention of disease to one’s genetic composition, is one that has been known and sought for many years. Increasingly, molecular companion diagnostics based on one’s inherited or somatic biomarkers are desired to ensure the effective, safe develop ment and application of a personalized drug. This has been ref...
متن کاملIn situ Protein Detection for Companion Diagnostics
The emergence of targeted therapies for cancer has created a need for the development of companion diagnostic tests. Assays developed in recent years are aimed at determining both the effectiveness and safety of specific drugs for a defined group of patients, thus, enabling the more efficient design of clinical trials and also supporting physicians when making treatment-related decisions. Immun...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2013
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2012.185132